MLB Best NRFI Bets Today – May 6, 2025

Thanks to a doubleheader between the Guardians and Nats, Tuesday’s MLB slate is jam-packed with 16 games across the diamond.

With such a loaded Tuesday schedule, what better time to unload on a few of our favorite NRFI bets than now?
Using the amazing BestOdds NRFI Pro betting suite we have honed in on our three favorite NRFI bets of the night. Here’s what we have on our betting cards.

Note: Odds were correct at the time of writing.

Astros-Brewers NRFI (-120) at BetMGM

The recipe for the perfect NRFI bet involves strong pitching and offenses that struggle to score in the first inning. Fortunately for NRFI bettors like us, Tuesday’s Houston–Milwaukee matchup checks both boxes.

First things first: the Astros average the fewest first-inning runs this season and are now without their dangerous slugger, Yordan Alvarez, who’s sidelined with an injury. The Brewers, meanwhile, score the third-fewest first-inning runs at home. Neither team has posed much of a threat early in games.

Then there’s the pitching matchup: Hayden Wesneski vs. Chad Patrick. According to BestOdds NRFI Pro, both starters have been electric in the opening frame.

At a solid price of -120, this feels like a no-brainer NRFI bet to lock in.

Hayden Wesneski-Chad Patrick 2025 NRFI stats (BestOdds NRFI Pro)

Odds Comparison for HOU-MIL NRFI

Sportsbook	Odds
BetMGM	-120 (Best Odds)
Caesars	-120 (Best Odds)
DraftKings	-120 (Best Odds)
FanDuel	-120 (Best Odds)
bet365	-125

White Sox-Royals NRFI (-105) at BetMGM

If you’re hesitant to back a NRFI involving one of the worst teams in baseball, I get it. Any bet counting on the White Sox not to give up runs can make your heart race.

That said, tonight’s matchup features one of the few pitchers in the White Sox rotation who has actually looked decent (and yes, we’re grading on a curve here) through the first month plus of the season.

Sean Burke has a 2-4 record with an ERA just under 5.00, but over his last two starts, he’s thrown 11 innings and allowed just three runs combined. Tonight, he faces the 27th-ranked offense in baseball in the form of the Royals’ top of the order.

On the other side, the Royals will send out Seth Lugo, who has been excellent at delivering scoreless first innings, doing so in six of his seven starts this season.

Ultimately, this bet likely hinges on how Burke handles the Royals’ bats. If he can maintain his recent form, this NRFI has a strong chance of cashing.

Sean Burke-Seth Lugo 2025 NRFI stats (BestOdds NRFI Pro)

Odds Comparison for CHW-KC NRFI

Sportsbook	Odds
BetMGM	-105 (Best Odds)
Caesars	-110
DraftKings	-110
bet365	-115
FanDuel	-115

Pirates-Cardinals NRFI (-145) at BetMGM

Our last NRFI bet of the night comes from the NL Central, where simply saying “Paul Skenes is starting” might be reason enough to back the NRFI.

However, Cardinals starter Matthew Liberatore has been no slouch either. When it comes to cashing NRFI tickets, he’s been nearly as reliable in the first inning as his counterpart tonight.

Through his first six starts of the season, Liberatore has recorded a scoreless first inning in five of them. He has only allowed two home runs all season, which is huge for NRFI bets. With the Pirates’ offense ranking near the bottom of the league, I expect him to handle the top of their lineup while Skenes takes care of business on the other side.

As will be the case for any start Skenes makes this season, you’ll have to pay a bit of juice to back the NRFI. Still, this one looks as strong as any NRFI play on the board tonight.

Paul Skenes-Matthew Liberatore 2025 NRFI stats (BestOdds NRFI Pro)

Odds Comparison for PIT-STL NRFI

Sportsbook	Odds
BetMGM	-145 (Best Odds)
DraftKings	-145 (Best Odds)
Caesars	-149
bet365	-150
FanDuel	-154