2025 NFC West Betting Odds

Out of the eight divisions in the National Football League, only one can claim to have three undefeated teams through the first two weeks of the season.

That division is the NFC West.

Prior to the start of the 2025 NFL season, all eyes were on the division races in the NFC North and AFC West, and for good reason, as each of those divisions is strong in its own right.

However, the opportunity was there for the NFC West to put together a season similar to what the NFC North accomplished just one year ago.

Entering Week 3, the Rams, 49ers, and Cardinals all sit at 2-0. The lone team without a perfect record is the Seattle Seahawks, and if not for Riq Woolen playing defensive back like his controller died in the middle of a Madden game, the Seahawks and 49ers might have traded places.

For those wondering why the NFC West has suddenly surged into the conversation as a division with the potential to send multiple teams to the postseason, look no further than the schedule.

Each member of the NFC West plays eight games against the two worst divisions in football: the AFC South and NFC South.

That is the same formula the NFC North used last season when its first-place team finished with 15 wins, its second-place team with 14, and its third-place team with 11.

So it should surprise no one that, of the eight games featuring NFC West teams so far this season, six have come against opponents from the AFC or NFC South. The 1-1 Seahawks are the only NFC West team that has not faced one of those divisions yet.

Before we jump into the state of the NFC West after two weeks of play, here is how the odds to win the division look as we enter Week 3.

Odds to Win 2025 NFC West Entering Week 3

Team	Current Odds to Win NFC West	Preseason Odds to Win NFC West
San Francisco 49ers	+150	+145
Los Angeles Rams	+175	+200
Arizona Cardinals	+360	+420
Seattle Seahawks	+850	+550

The only significant movement in the odds to win the NFC West has come from the Seahawks, who dropped to +850 following their opening-week loss to the 49ers. The rest of the division has seen only gradual shifts through the first two weeks of the season.

The current odds-on favorite to win the division is the 49ers, who are still navigating a wave of injuries. Most recently, starting quarterback Brock Purdy missed their Week 2 game against the Saints with shoulder and toe injuries and is not expected back for a few more weeks. This comes after the Niners lost George Kittle to a hamstring injury following his opening touchdown in their Week 1 victory over Seattle, and with Brandon Aiyuk still recovering from the ACL injury that ended his 2024 season.

The practical co-favorite entering Week 3 is Sean McVay’s Rams. Not only are they 2-0 and leading the NFC West, but they would also be on top of the AFC South after opening with wins over the Texans and Titans.

The Rams played a hard-fought opener but looked especially rusty on offense, likely a result of Matthew Stafford missing most of training camp and all of the preseason. They looked more like the team fans expected in their decisive win over the Titans this past Sunday.

The Cardinals are also 2-0, though they have had the softest schedule so far with wins over the Saints and Panthers, both teams more likely to contend for the No. 1 overall pick in the 2026 NFL Draft than for a playoff spot. Their upcoming schedule is much tougher, with an eight-game stretch in which they may be favored only twice.

Lastly, the Seahawks continue to fly under the radar, largely because of skepticism surrounding new starting quarterback Sam Darnold.

However, their defense has been outstanding through the first two weeks, and seeing them listed at +850 feels like an overreaction to a Week 1 loss they very easily could, and arguably should, have won.

2025 NFC West Win Totals

There is no better way to understand how a division is perceived by the oddsmakers than looking at team win totals as the season goes on.

Here’s how the NFC West shakes out in the win total department following the first two weeks of the season.

Team	Current Win Totals and Betting Odds	Preseason Win Totals and Betting Odds
San Francisco 49ers	O/U 10.5 | (-145/+125)	O/U 10.5 | (-120/+100)
Los Angeles Rams	O/U 10.5 | (-120/+100)	O/U 9.5 | (-125/+105)
Arizona Cardinals	O/U 9.5 | (-110/-110)	O/U 8.5 | (-115/-105)
Seattle Seahawks	O/U 8.5 | (+100/-120)	O/U 8.5 | (+115/-135)

• In what will be a common theme for all four members of the NFC West, the Niners win total odds remain mostly unchanged from their preseason projected win total. Entering Week 3, the Niners are still projected to win 10.5 games this season, with the juice now a bit more weighted towards the over at -145.
  
  
• Thanks to their 2-0 start, the Rams projected win total has been bumped from 9.5 to 10.5. It should be noted that while Sean McVay has been incredibly successful in his nine seasons as Rams head coach, he has won 11+ games in a season only three times.
  
  
• The Cardinals have won 10 games or more in a season only one time in the last nine years, however, oddsmakers believe double-digit wins are in play this season after Arizona’s 2-0 start to the year. 
  
  
• The Seahawks preseason odds remain mostly unchanged, with only a slight bump up in their odds to win 8.5 games or more this season. However, as mentioned at the top of this article, they’re the only team in the division yet to play a game against the AFC or NFC North, with their first such matchup coming in Week 3 against the Saints. This still feels like a team that is deeply underrated in this division.

2025 NFC West – To Win Super Bowl 60 Odds

The NFC West have been well represented in the Super Bowl over the last 15 years, with only the Cardinals not making it to the NFL’s final game, and the Rams and Seahawks each winning Super Bowl’s.

Here’s a look at how the Super Bowl futures market looks for the NFC West as we enter Week 3.

NFC West Teams – Super Bowl LX Odds

Team	Current Odds to Win Super Bowl LX	Preseason Odds to Win Super Bowl LX
Los Angeles Rams	+1800	+1900
San Francisco 49ers	+1900	+1800
Arizona Cardinals	+3500	+4000
Seattle Seahawks	+7000	+6000

Entering Week 3, the odds to win Super Bowl 60 in Santa Clara have remained largely unchanged from their preseason odds, with the Rams and 49ers swapping places on the odds board and the Cardinals seeing a modest bump from 40-1 to 35-1.

The Seahawks have seen a modest dip from 60-1 prior to the start of the season to 70-1 entering Week 3, however, for those bettors who love to take a dart throw on a deep sleeper to win the Super Bowl, the Seahawks look to be the best option at the moment. Again, I want to reiterate, go look at this team’s schedule. They’re likely not going to win the Super Bowl, but they could certainly be in the playoffs.

2025 NFC West – Player MVP Odds

It’s undeniable now that the NFL MVP award is essentially just a coronation of what quarterback had the best season from the best team.

Here’s a look at how the NFC West quarterbacks measure up in this season’s race to be NFL MVP after the first two weeks of the season.

Player	Current Odds to Win NFL MVP	Preseason Odds to Win NFL MVP
Matthew Stafford (Rams)	+2500	+4000
Kyler Murray (Cardinals)	+5000	+5000
Brock Purdy (49ers)	+6000	+2800
Sam Darnold (Seahawks)	+10000	+10000

Matthew Stafford appears to be the only NFC West quarterback with a chance to win the NFL MVP Award, as Brock Purdy’s injury severely damaged his chances to put himself in the mix for the honors.

Kyler Murray and Sam Darnold’s MVP odds have not moved an inch, as both quarterbacks remain with the same odds as they had leading up to the start of the season.

Step-By-Step To Bet On Divisional Winners

1. Go to your favorite sportsbook and log in.
2. Look for the NFL tab.
3. Click on the Division’s tab from the drop-down menu.
4. Choose the odds and team you will bet on.
5. Place your bet from the bet slip window—usually—on the right side of the screen.

Betting Odds For NFC Divisions

2025 NFC South Division Odds

2025 NFC North Division Odds

2025 NFC East Division Odds