Week 1 of the NFL season is in the books and bettors at least have a better feel of some of the teams to watch out for as the gridiron action plays out this week.

A few teams impressed – including the Kansas City Chiefs with an solid win and cover at home to kick off the season.

The Cowboys also notched an impressive road win after going into Cleveland as a three-point underdog.

The 49ers remain the team to beat in the NFC after dismantling the Jets on Monday Night Football and the Lions also covered for bettors with a nice win over the Rams.

With a big matchup set for Thursday between the Bills and Dolphins, here’s a look at what to expect with this week’s NFL betting lines.

Week 2 Matchups to Watch

Week 2 brings about some nice matchups to check out. Can some of those Week 1 winners continue paying off for bettors?

Are there a few struggling teams that might be worth targeting throughout the season, such as the Panthers and Giants?

These are definitely some factors to watch. Here’s a look at some big games to check out this week:

• Bills at Dolphins – Two major AFC contenders battle in a key divisional matchup on Thursday Night Football. 
• Saints at Cowboys – New Orleans had a massive 47-10 Week 1 win against the Panthers, but faces a much tougher test when heading to Dallas.
• Seahawks at Patriots – Are thePatriots for real? They have a chance to prove it here after dispatching of the Bengals – and costing plenty of bettors – in Week 1.
• Tampa Bay at Detroit – The Bucs have a chance to send a statement here but are up against a tough Lions squad that just seems to find a way to win and may be better than last year.

Week 2 NFL Odds

Ready to make those predictions? Here’s a look at this week’s odds, courtesy of FanDuel.

Matchup	Betting Line	Moneyline	Total
Bills at Dolphins	Bills 2.5	Bills +122 Dolphins -144	48.5
Saints at Cowboys	Cowboys 6.5	Saints +230 Cowboys -280	46.5
Buccaneers at Lions	Lions -7.5	Buccaneers +265 Lions -330	51.5
Browns at Jaguars	Jaguars -3	Browns +138 Jaguars -164	41.5
49ers at Vikings	49ers -5.5	49ers -235 Vikings +194	46.5
Chargers at Panthers	Chargers -5.5	Chargers -260 Panthers +215	38.5
Raiders at Ravens	Ravens -8.5	Raiders +370 Ravens -480	41.5
Seahawks at Patriots	Seahawks -3.5	Seahawks -194 Patriots +162	38.5
Colts at Packers	Colts -3	Colts -150 Packers +132	40.5
Jets at Titans	Jets -4	Jets -205 Titans +172	41.5
Giants at Commanders	Commenders -1.5	Giants -102 Commanders -116	42.5
Rams at Cardinals	Rams -1.5	Rams +102 Cardinals –120	47.5
Bengals at Chiefs	Chiefs -5.5	Bengals +194 Chiefs -235	47.5
Steelers at Broncos	Steelers -2.5	Steelers -154 Broncos +130	36.5
Bears at Texans	Texans -6.5	Bears +240 Texans -295	45.5
Falcons at Eagles	Eagles -6.5	Falcons +260 Eagles -320	47.5

Interesting Prop Bets

Keep an eye on Commanders quarterback Jayden Daniels against what looks to be another poor Giants squad.

New York struggled in Week 1 against the Vikings and the Commanders look to be improved this year.

Daniels chalked up 71 yards on the ground last week seems like to go over 51.5 yards for a rushing yards player prop bet this week.

Picks for the People

Last week saw a few teams surprise and our picks finished 3-3 including Lamar Jackson easily topping 48.5 yards rushing for a win on that player prop.

This week’s picks look to do better and target a few teams that struggled in Week 1.

• Bills at Dolphins – Miami seemed a little unsteady in Week 1 and the Bills rewarded bettors with a nice win over the Cardinals. Take the Bills to and the 2.5 points.
• Giants at Commanders – The G-men looked awful in Week 1. The Commanders are looking for an upswing this week and quarterback Jayden Daniels should top 51.5 yards and also lead Washington to a victory of more than the 1.5.
• Chargers at Carolina – The Panthers once again lack any sort of real growl. After a tough Week 1, look for Chargers coach Jim Harbaugh and quarterback Justin Herbert to move to 2-0 this week and top the 5.5 points.
• 49ers at Vikings – The Niners are an NFC powerhouse and get it done this week as well – covering the 5.5.
• Chiefs at Bengals – Perhaps Joe Burrow is still hurt after all? The Bengals had only 224 yards of total offense last week against the Patriots and may struggle again this week against the Chiefs. KC should cover the 5.5 points.

If you’re looking for player props and parlay picks for this week, check out our dedicated articles:

• Week 2 Props
• Week 2 Parlays